Determinants of weight evolution among HIV-positive patients initiating antiretroviral treatment in low resource settings
Identifieur interne : 002F45 ( Main/Exploration ); précédent : 002F44; suivant : 002F46Determinants of weight evolution among HIV-positive patients initiating antiretroviral treatment in low resource settings
Auteurs : D. Huis In Veld [Belgique] ; E. Balestre [France] ; J. Buyze [Belgique] ; J. Menten [Belgique] ; A. Jaquet [France] ; D. A. Cooper [Australie] ; F. Dabis [France] ; C. T. Yiannoutsos [États-Unis] ; L. Diero ; P. Mutevedzi [Afrique du Sud, Royaume-Uni] ; M. P. Fox [États-Unis, Afrique du Sud] ; E. Messou [Côte d'Ivoire] ; C. J. Hoffmann [Afrique du Sud, États-Unis] ; H. W. Prozesky [Afrique du Sud] ; M. Egger [Suisse, Afrique du Sud] ; J. J. Hemingway-Foday [États-Unis] ; R. Colebunders [Belgique]Source :
- Journal of acquired immune deficiency syndromes (1999) [ 1525-4135 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- administration et posologie : Agents antiVIH.
- effets indésirables : Agents antiVIH.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH.
- Adolescent, Adulte, Femelle, Humains, Jeune adulte, Mâle, Pauvreté, Poids du corps.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Anti-HIV Agents.
- chemical , adverse effects : Anti-HIV Agents.
- chemical , therapeutic use : Anti-HIV Agents.
- drug effects : Body Weight.
- drug therapy : HIV Infections.
- Adolescent, Adult, Female, Humans, Male, Poverty, Young Adult.
Abstract
In resource limited settings clinical parameters, including body weight changes, are used to monitor clinical response. Therefore we studied body weight changes in patients on antiretroviral treatment (ART) in different regions of the world.
Data were extracted from the “International Epidemiologic Databases to Evaluate AIDS”, a network of ART programmes that prospectively collects routine clinical data. Adults on ART from the Southern-, East-, West- and Central African and the Asia-Pacific regions were selected from the database if baseline data on body weight, gender, ART regimen and CD4 count were available. Body weight change over the first two years and the probability of body weight loss in the second year were modelled using linear mixed models and logistic regression respectively.
Data from 205,571 patients were analysed. Mean adjusted body weight change in the first 12 months was higher in patients started on tenofovir and/or efavirenz; in patients from Central, West and East Africa, in men, and in patients with a poorer clinical status. In the second year of ART it was greater in patients initiated on tenofovir and/or nevirapine, and for patients not on stavudine, in women, in Southern Africa and in patients with a better clinical status at initiation. Stavudine in the initial regimen was associated with a lower mean adjusted body weight change and with weight loss in the second treatment year.
Different ART regimens have different effects on body weight change. Body weight loss after one year of treatment in patients on stavudine might be associated with lipoatrophy.
Url:
DOI: 10.1097/QAI.0000000000000691
PubMed: 26375465
PubMed Central: 4576726
Affiliations:
- Afrique du Sud, Australie, Belgique, Côte d'Ivoire, France, Royaume-Uni, Suisse, États-Unis
- Angleterre, Aquitaine, Canton de Berne, Caroline du Nord, Gauteng, Grand Londres, Indiana, Maryland, Massachusetts, Nouvelle-Aquitaine, Nouvelle-Galles du Sud, Province d'Anvers, Région de Bruxelles-Capitale, Région flamande
- Anvers, Baltimore, Berne, Bordeaux, Bruxelles, Johannesbourg, Londres, Sydney
- University College de Londres, Université d'Anvers, Université de Berne, Université du Witwatersrand
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Le document en format XML
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Messou</name><affiliation wicri:level="1"><nlm:aff id="A13">Centre de prise en charge de recherche et de formation (CePReF), Hôpital Yopougon Attié, Abidjan, Côte d'Ivoire</nlm:aff><country xml:lang="fr">Côte d'Ivoire</country><wicri:regionArea>Centre de prise en charge de recherche et de formation (CePReF), Hôpital Yopougon Attié, Abidjan</wicri:regionArea><wicri:noRegion>Abidjan</wicri:noRegion></affiliation></author><author><name sortKey="Hoffmann, C J" sort="Hoffmann, C J" uniqKey="Hoffmann C" first="C. J." last="Hoffmann">C. J. Hoffmann</name><affiliation wicri:level="1"><nlm:aff id="A14">The Aurum Institute, Johannesburg, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>The Aurum Institute, Johannesburg</wicri:regionArea><wicri:noRegion>Johannesburg</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">John Hopkins University, Baltimore, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>John Hopkins University, Baltimore</wicri:regionArea><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Prozesky, H W" sort="Prozesky, H W" uniqKey="Prozesky H" first="H. W." last="Prozesky">H. W. Prozesky</name><affiliation wicri:level="1"><nlm:aff id="A16">Division of Infectious Diseases, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Cape Town, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Infectious Diseases, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Egger, M" sort="Egger, M" uniqKey="Egger M" first="M." last="Egger">M. Egger</name><affiliation wicri:level="4"><nlm:aff id="A17">Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region><settlement type="city">Berne</settlement></placeName><orgName type="university">Université de Berne</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A18">Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town</wicri:regionArea><wicri:noRegion>University of Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Hemingway Foday, J J" sort="Hemingway Foday, J J" uniqKey="Hemingway Foday J" first="J. J." last="Hemingway-Foday">J. J. Hemingway-Foday</name><affiliation wicri:level="2"><nlm:aff id="A19">RTI International, Research Triangle Park, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>RTI International, Research Triangle Park, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Colebunders, R" sort="Colebunders, R" uniqKey="Colebunders R" first="R." last="Colebunders">R. Colebunders</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Clinical Sciences Department, Institute of Tropical Medicine, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26375465</idno><idno type="pmc">4576726</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576726</idno><idno type="RBID">PMC:4576726</idno><idno type="doi">10.1097/QAI.0000000000000691</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001D67</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D67</idno><idno type="wicri:Area/Pmc/Curation">001C23</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C23</idno><idno type="wicri:Area/Pmc/Checkpoint">001076</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001076</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002839</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002839</idno><idno type="wicri:Area/PubMed/Curation">002770</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002770</idno><idno type="wicri:Area/PubMed/Checkpoint">002770</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002770</idno><idno type="wicri:Area/Ncbi/Merge">002A68</idno><idno type="wicri:Area/Ncbi/Curation">002A68</idno><idno type="wicri:Area/Ncbi/Checkpoint">002A68</idno><idno type="wicri:doubleKey">1525-4135:2015:Huis In Veld D:determinants:of:weight</idno><idno type="wicri:Area/Main/Merge">002F46</idno><idno type="wicri:Area/Main/Curation">002F45</idno><idno type="wicri:Area/Main/Exploration">002F45</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Determinants of weight evolution among HIV-positive patients initiating antiretroviral treatment in low resource settings</title><author><name sortKey="Huis In Veld, D" sort="Huis In Veld, D" uniqKey="Huis In Veld D" first="D." last="Huis In Veld">D. Huis In Veld</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Clinical Sciences Department, Institute of Tropical Medicine, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A3">Fonds Wetenschappelijk Onderzoek-Vlaanderen. Aspirant Mandate holder. FWO, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Fonds Wetenschappelijk Onderzoek-Vlaanderen. Aspirant Mandate holder. FWO, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Balestre, E" sort="Balestre, E" uniqKey="Balestre E" first="E." last="Balestre">E. Balestre</name><affiliation wicri:level="3"><nlm:aff id="A4">Université Bordeaux, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Bordeaux, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, F-33000 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Buyze, J" sort="Buyze, J" uniqKey="Buyze J" first="J" last="Buyze">J. Buyze</name><affiliation wicri:level="1"><nlm:aff id="A2">Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Clinical Sciences Department, Institute of Tropical Medicine, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Menten, J" sort="Menten, J" uniqKey="Menten J" first="J." last="Menten">J. Menten</name><affiliation wicri:level="1"><nlm:aff id="A2">Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Clinical Sciences Department, Institute of Tropical Medicine, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Jaquet, A" sort="Jaquet, A" uniqKey="Jaquet A" first="A." last="Jaquet">A. Jaquet</name><affiliation wicri:level="1"><nlm:aff id="A4">Université Bordeaux, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Bordeaux, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, F-33000 Bordeaux</wicri:regionArea><wicri:noRegion>33000 Bordeaux</wicri:noRegion><wicri:noRegion>33000 Bordeaux</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A5">ISPED, Centre INSERM U 897-Epidemiologie-Biostatistique, University of Bordeaux, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>ISPED, Centre INSERM U 897-Epidemiologie-Biostatistique, University of Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Cooper, D A" sort="Cooper, D A" uniqKey="Cooper D" first="D. A." last="Cooper">D. A. Cooper</name><affiliation wicri:level="3"><nlm:aff id="A6">Kirby Institute University of New South Wales and Centre for Applied Medical Research, St Vincent’s Hospital, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Kirby Institute University of New South Wales and Centre for Applied Medical Research, St Vincent’s Hospital, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Dabis, F" sort="Dabis, F" uniqKey="Dabis F" first="F." last="Dabis">F. Dabis</name><affiliation wicri:level="3"><nlm:aff id="A4">Université Bordeaux, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Bordeaux, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, F-33000 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A5">ISPED, Centre INSERM U 897-Epidemiologie-Biostatistique, University of Bordeaux, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>ISPED, Centre INSERM U 897-Epidemiologie-Biostatistique, University of Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Yiannoutsos, C T" sort="Yiannoutsos, C T" uniqKey="Yiannoutsos C" first="C. T." last="Yiannoutsos">C. T. Yiannoutsos</name><affiliation wicri:level="2"><nlm:aff id="A7">Department of Biostatistics, Indiana University School of Public Health, Indianapolis, IN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Indiana University School of Public Health, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Diero, L" sort="Diero, L" uniqKey="Diero L" first="L." last="Diero">L. Diero</name><affiliation><nlm:aff id="A8">Department of Medicine, Moi University/Ampath Eldoret Kenya</nlm:aff><wicri:noCountry code="subfield">Moi University/Ampath Eldoret Kenya</wicri:noCountry></affiliation></author><author><name sortKey="Mutevedzi, P" sort="Mutevedzi, P" uniqKey="Mutevedzi P" first="P." last="Mutevedzi">P. Mutevedzi</name><affiliation wicri:level="1"><nlm:aff id="A9">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele</wicri:regionArea><wicri:noRegion>Somkhele</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A10">Department of Infection and Population Health, University College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infection and Population Health, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Fox, M P" sort="Fox, M P" uniqKey="Fox M" first="M. P." last="Fox">M. P. Fox</name><affiliation wicri:level="2"><nlm:aff id="A11">Centre for Global Health & Development, Boston University, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Centre for Global Health & Development, Boston University, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A12">Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand</nlm:aff><country>Afrique du Sud</country><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName><orgName type="university">Université du Witwatersrand</orgName></affiliation></author><author><name sortKey="Messou, E" sort="Messou, E" uniqKey="Messou E" first="E." last="Messou">E. Messou</name><affiliation wicri:level="1"><nlm:aff id="A13">Centre de prise en charge de recherche et de formation (CePReF), Hôpital Yopougon Attié, Abidjan, Côte d'Ivoire</nlm:aff><country xml:lang="fr">Côte d'Ivoire</country><wicri:regionArea>Centre de prise en charge de recherche et de formation (CePReF), Hôpital Yopougon Attié, Abidjan</wicri:regionArea><wicri:noRegion>Abidjan</wicri:noRegion></affiliation></author><author><name sortKey="Hoffmann, C J" sort="Hoffmann, C J" uniqKey="Hoffmann C" first="C. J." last="Hoffmann">C. J. Hoffmann</name><affiliation wicri:level="1"><nlm:aff id="A14">The Aurum Institute, Johannesburg, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>The Aurum Institute, Johannesburg</wicri:regionArea><wicri:noRegion>Johannesburg</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">John Hopkins University, Baltimore, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>John Hopkins University, Baltimore</wicri:regionArea><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Prozesky, H W" sort="Prozesky, H W" uniqKey="Prozesky H" first="H. W." last="Prozesky">H. W. Prozesky</name><affiliation wicri:level="1"><nlm:aff id="A16">Division of Infectious Diseases, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Cape Town, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Infectious Diseases, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Egger, M" sort="Egger, M" uniqKey="Egger M" first="M." last="Egger">M. Egger</name><affiliation wicri:level="4"><nlm:aff id="A17">Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region><settlement type="city">Berne</settlement></placeName><orgName type="university">Université de Berne</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A18">Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town</wicri:regionArea><wicri:noRegion>University of Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Hemingway Foday, J J" sort="Hemingway Foday, J J" uniqKey="Hemingway Foday J" first="J. J." last="Hemingway-Foday">J. J. Hemingway-Foday</name><affiliation wicri:level="2"><nlm:aff id="A19">RTI International, Research Triangle Park, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>RTI International, Research Triangle Park, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Colebunders, R" sort="Colebunders, R" uniqKey="Colebunders R" first="R." last="Colebunders">R. Colebunders</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Clinical Sciences Department, Institute of Tropical Medicine, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of acquired immune deficiency syndromes (1999)</title><idno type="ISSN">1525-4135</idno><idno type="eISSN">1944-7884</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Anti-HIV Agents (administration & dosage)</term><term>Anti-HIV Agents (adverse effects)</term><term>Anti-HIV Agents (therapeutic use)</term><term>Body Weight (drug effects)</term><term>Female</term><term>HIV Infections (drug therapy)</term><term>Humans</term><term>Male</term><term>Poverty</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Agents antiVIH (administration et posologie)</term><term>Agents antiVIH (effets indésirables)</term><term>Agents antiVIH (usage thérapeutique)</term><term>Femelle</term><term>Humains</term><term>Infections à VIH (traitement médicamenteux)</term><term>Jeune adulte</term><term>Mâle</term><term>Pauvreté</term><term>Poids du corps ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Agents antiVIH</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Body Weight</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Agents antiVIH</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Poverty</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Pauvreté</term><term>Poids du corps</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">In resource limited settings clinical parameters, including body weight changes, are used to monitor clinical response. Therefore we studied body weight changes in patients on antiretroviral treatment (ART) in different regions of the world.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Data were extracted from the “International Epidemiologic Databases to Evaluate AIDS”, a network of ART programmes that prospectively collects routine clinical data. Adults on ART from the Southern-, East-, West- and Central African and the Asia-Pacific regions were selected from the database if baseline data on body weight, gender, ART regimen and CD4 count were available. Body weight change over the first two years and the probability of body weight loss in the second year were modelled using linear mixed models and logistic regression respectively.</p></sec><sec id="S3"><title>Results</title><p id="P3">Data from 205,571 patients were analysed. Mean adjusted body weight change in the first 12 months was higher in patients started on tenofovir and/or efavirenz; in patients from Central, West and East Africa, in men, and in patients with a poorer clinical status. In the second year of ART it was greater in patients initiated on tenofovir and/or nevirapine, and for patients not on stavudine, in women, in Southern Africa and in patients with a better clinical status at initiation. Stavudine in the initial regimen was associated with a lower mean adjusted body weight change and with weight loss in the second treatment year.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Different ART regimens have different effects on body weight change. Body weight loss after one year of treatment in patients on stavudine might be associated with lipoatrophy.</p></sec></div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Australie</li><li>Belgique</li><li>Côte d'Ivoire</li><li>France</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Canton de Berne</li><li>Caroline du Nord</li><li>Gauteng</li><li>Grand Londres</li><li>Indiana</li><li>Maryland</li><li>Massachusetts</li><li>Nouvelle-Aquitaine</li><li>Nouvelle-Galles du Sud</li><li>Province d'Anvers</li><li>Région de Bruxelles-Capitale</li><li>Région flamande</li></region><settlement><li>Anvers</li><li>Baltimore</li><li>Berne</li><li>Bordeaux</li><li>Bruxelles</li><li>Johannesbourg</li><li>Londres</li><li>Sydney</li></settlement><orgName><li>University College de Londres</li><li>Université d'Anvers</li><li>Université de Berne</li><li>Université du Witwatersrand</li></orgName></list><tree><noCountry><name sortKey="Diero, L" sort="Diero, L" uniqKey="Diero L" first="L." last="Diero">L. Diero</name></noCountry><country name="Belgique"><region name="Région flamande"><name sortKey="Huis In Veld, D" sort="Huis In Veld, D" uniqKey="Huis In Veld D" first="D." last="Huis In Veld">D. Huis In Veld</name></region><name sortKey="Buyze, J" sort="Buyze, J" uniqKey="Buyze J" first="J" last="Buyze">J. Buyze</name><name sortKey="Colebunders, R" sort="Colebunders, R" uniqKey="Colebunders R" first="R." last="Colebunders">R. Colebunders</name><name sortKey="Colebunders, R" sort="Colebunders, R" uniqKey="Colebunders R" first="R." last="Colebunders">R. Colebunders</name><name sortKey="Huis In Veld, D" sort="Huis In Veld, D" uniqKey="Huis In Veld D" first="D." last="Huis In Veld">D. Huis In Veld</name><name sortKey="Huis In Veld, D" sort="Huis In Veld, D" uniqKey="Huis In Veld D" first="D." last="Huis In Veld">D. Huis In Veld</name><name sortKey="Menten, J" sort="Menten, J" uniqKey="Menten J" first="J." last="Menten">J. Menten</name></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Balestre, E" sort="Balestre, E" uniqKey="Balestre E" first="E." last="Balestre">E. Balestre</name></region><name sortKey="Dabis, F" sort="Dabis, F" uniqKey="Dabis F" first="F." last="Dabis">F. Dabis</name><name sortKey="Dabis, F" sort="Dabis, F" uniqKey="Dabis F" first="F." last="Dabis">F. Dabis</name><name sortKey="Jaquet, A" sort="Jaquet, A" uniqKey="Jaquet A" first="A." last="Jaquet">A. Jaquet</name><name sortKey="Jaquet, A" sort="Jaquet, A" uniqKey="Jaquet A" first="A." last="Jaquet">A. Jaquet</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Cooper, D A" sort="Cooper, D A" uniqKey="Cooper D" first="D. A." last="Cooper">D. A. Cooper</name></region></country><country name="États-Unis"><region name="Indiana"><name sortKey="Yiannoutsos, C T" sort="Yiannoutsos, C T" uniqKey="Yiannoutsos C" first="C. T." last="Yiannoutsos">C. T. Yiannoutsos</name></region><name sortKey="Fox, M P" sort="Fox, M P" uniqKey="Fox M" first="M. P." last="Fox">M. P. Fox</name><name sortKey="Hemingway Foday, J J" sort="Hemingway Foday, J J" uniqKey="Hemingway Foday J" first="J. J." last="Hemingway-Foday">J. J. Hemingway-Foday</name><name sortKey="Hoffmann, C J" sort="Hoffmann, C J" uniqKey="Hoffmann C" first="C. J." last="Hoffmann">C. J. Hoffmann</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Mutevedzi, P" sort="Mutevedzi, P" uniqKey="Mutevedzi P" first="P." last="Mutevedzi">P. Mutevedzi</name></noRegion><name sortKey="Egger, M" sort="Egger, M" uniqKey="Egger M" first="M." last="Egger">M. Egger</name><name sortKey="Fox, M P" sort="Fox, M P" uniqKey="Fox M" first="M. P." last="Fox">M. P. Fox</name><name sortKey="Hoffmann, C J" sort="Hoffmann, C J" uniqKey="Hoffmann C" first="C. J." last="Hoffmann">C. J. Hoffmann</name><name sortKey="Prozesky, H W" sort="Prozesky, H W" uniqKey="Prozesky H" first="H. W." last="Prozesky">H. W. Prozesky</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mutevedzi, P" sort="Mutevedzi, P" uniqKey="Mutevedzi P" first="P." last="Mutevedzi">P. Mutevedzi</name></region></country><country name="Côte d'Ivoire"><noRegion><name sortKey="Messou, E" sort="Messou, E" uniqKey="Messou E" first="E." last="Messou">E. Messou</name></noRegion></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Egger, M" sort="Egger, M" uniqKey="Egger M" first="M." last="Egger">M. Egger</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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